The Role of Obesity in Cognitive Decline and Alzheimer’s Disease

by The Studio of Mental Health and Psychology

Nutrition, lifestyle and insufficient physical activity to control body weight are making the global population more vulnerable to obesity. The obese body abnormally accumulates adipose tissues, including white adipose tissue (WAT), which aberrantly generates and secretes adipokines (substances that exert autocrine, paracrine or endocrine effects on processes in the central nervous system and periphery), causing dysregulation of homeostatic systems. This leads to an elevated risk for comorbidities such as insulin resistance and type-2 diabetes, hypertension, atherosclerosis and other cardiovascular diseases, mood disorders, such as major depressive and bipolar disorder and cognitive disorders, such as Alzheimer’s disease.

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